26-year-old patient with three-year long alcohol abuse history was admitted to our hospital due to jaundice. She was previously well, didn’t use medications but took an Ashwagandha supplement daily for a few months. Laboratory findings showed severely increased alanine and aspartate aminotransferases, biochemical signs of cholestasis and increased level of bilirubin. Moreover, anti-HCV was detected and viral hepatitis was confirmed with detection of HCV RNA. According to RUCAM score Ashwagandha could be linked as a culprit of liver injury. During hospital stay after observing rise in bilirubin levels the liver biopsy was performed. The following description highlights the challenges involved in establishing a diagnosis of drug induced liver injury and emphasises role of liver histopathology in claryfying diagnostic issues.